Oral Oncology
Volume 37, Issue 7 , Pages 566-571 , October 2001

Amplification and protein expression of chromosome 12q13-15 genes in osteosarcomas of the jaws

  • M.A. Lopes

      Affiliations

    • Department of Oral Diagnosis, Faculty of Odontology of Piracicaba, UNICAMP, São Paulo, Brazil
    • Corresponding Author InformationCorresponding author. Present address: Department of Oral and Maxillofacial Pathology, Dental School, University of Maryland, 666 West Baltimore Street, Baltimore, MD 21201 USA. Tel.: +1-410-706-7936; fax: +1-410-706-0193
  • ,
  • N.G. Nikitakis

      Affiliations

    • Department of Pathology, University of Maryland at Baltimore, Baltimore, Maryland, USA
  • ,
  • R.A. Ord

      Affiliations

    • Dental School and UMAB Greenebaum Cancer Center, University of Maryland at Baltimore, Baltimore, Maryland, USA
  • ,
  • J. Sauk Jr.

      Affiliations

    • Department of Pathology, University of Maryland at Baltimore, Baltimore, Maryland, USA
    • Dental School and UMAB Greenebaum Cancer Center, University of Maryland at Baltimore, Baltimore, Maryland, USA

Received 21 August 2000 ,Revised 10 October 2000 ,Accepted 10 October 2000.

References 

  1. Huvos AG. Bone tumors: diagnosis, treatment, and prognosis. 2nd ed. Philadelphia: WB Saunders; 1991;
  2. Antman KH, Eilber FR, Shiu MH. Soft tissue sarcomas: current trends in diagnosis and management. Curr Probl Cancer. 1989;13(6):337–367
  3. Wanebo HJ, Koness RJ, MacFarlane JK, Eilber FR, Byers RM, Elias EG, et al.  Head and neck sarcoma: report of the Head and Neck Sarcoma Registry. Society of Head and Neck Surgeons Committee on Research. Head Neck. 1992;14(1):1–7
  4. Vege DS, Borges AM, Aggrawal K, Balasubramaniam G, Parikh DM, Bhaser B. Osteosarcoma of the craniofacial bones. A clinico-pathological study. J Craniomaxillofac Surg. 1991;19(2):90–93
  5. Delgado R, Maafs E, Alfeiran A, Mohar A, Barrera JL, Zinser J, et al.  Osteosarcoma of the jaw. Head Neck. 1994;16(3):246–252
  6. Mark RJ, Sercarz JA, Tran L, Dodd LG, Selch M, Calcaterra TC. Osteogenic sarcoma of the head and neck. The UCLA experience. Arch Otolaryngol Head Neck Surg. 1991;117(7):761–766
  7. Smeele LE, Kostense PJ, van der Waal I, Snow GB. Effect of chemotherapy on survival of craniofacial osteosarcoma: a systematic review of 201 patients. J Clin Oncol. 1997;15(1):363–367
  8. Wunder JS, Eppert K, Burrow SR, Gogkoz N, Bell RS, Andrulis IL. Co-amplification and overexpression of CDK4, SAS and MDM2 occurs frequently in human parosteal osteosarcomas. Oncogene. 1999;18(3):783–788
  9. Leach FS, Tokino T, Meltzer P, Burrell M, Oliner JD, Smith S, et al.  p53 Mutation and MDM2 amplification in human soft tissue sarcomas. Cancer Res. 1993;53(10 Suppl):2231–2234
  10. Meltzer PS. MDM2 and p53: a question of balance. J Natl Cancer Inst. 1994;86(17):1265–1266
  11. Barak Y, Juven T, Haffner R, Oren M. mdm2 expression is induced by wild type p53 activity. EMBO J. 1993;12(2):461–468
  12. Oliner JD, Kinzler KW, Meltzer PS, George DL, Vogelstein B. Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature. 1992;358(6381):80–83
  13. Momand J, Zambetti GP, Olson DC, George D, Levine AJ. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell. 1992;69(7):1237–1245
  14. Kato J, Matsushime H, Hiebert SW, Ewen ME, Sherr CJ. Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4. Genes Dev. 1993;7(3):331–342
  15. Matsushime H, Quelle DE, Shurtleff SA, Shibuya M, Sherr CJ, Kato JY. D-type cyclin-dependent kinase activity in mammalian cells. Mol Cell Biol. 1994;14(3):2066–2076
  16. Khatib ZA, Matsushime H, Valentine M, Shapiro DN, Sherr CJ, Look AT. Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas. Cancer Res. 1993;53(22):5535–5541
  17. Ewen ME, Sluss HK, Sherr CJ, Matsushime H, Kato J, Livingston DM. Functional interactions of the retinoblastoma protein with mammalian D-type cyclins. Cell. 1993;73(3):487–497
  18. Meltzer PS, Jankowski SA, Dal Cin P, Sandberg AA, Paz IB, Coccia MA. Identification and cloning of a novel amplified DNA sequence in human malignant fibrous histiocytoma derived from a region of chromosome 12 frequently rearranged in soft tissue tumors. Cell Growth Differ. 1991;2(10):495–501
  19. Jankowski SA, Mitchell DS, Smith SH, Trent JM, Meltzer PS. SAS, a gene amplified in human sarcomas, encodes a new member of the transmembrane 4 superfamily of proteins. Oncogene. 1994;9(4):1205–1211
  20. Jankowski SA, De Jong P, Meltzer PS. Genomic structure of SAS, a member of the transmembrane 4 superfamily amplified in human sarcomas. Genomics. 1995;25(2):501–506
  21. Berner JM, Forus A, Elkahloun A, Meltzer PS, Fodstad O, Myklebost O. Separate amplified regions encompassing CDK4 and MDM2 in human sarcomas. Genes Chromosomes Cancer. 1996;17(4):254–259
  22. Nilbert M, Rydholm A, Mitelman F, Meltzer PS, Mandahl N. Characterization of the 12q13-15 amplicon in soft tissue tumors. Cancer Genet Cytogenet. 1995;83(1):32–36
  23. Reifenberger G, Ichimura K, Reifenberger J, Elkahloun AG, Meltzer PS, Collins VP. Refined mapping of 12q13-q15 amplicons in human malignant gliomas suggests CDK4/SAS and MDM2 as independent amplification targets. Cancer Res. 1996;56(22):5141–5145
  24. Elkahloun AG, Bittner M, Hoskins K, Gemmill R, Meltzer PS. Molecular cytogenetic characterization and physical mapping of 12q13-15 amplification in human cancers. Genes Chromosomes Cancer. 1996;17(4):205–214
  25. Sambrook J, Fritsch EF, Maniatis T. Analysis and cloning of eukaryotic genomic DNA. In: Nolan C, editor. Molecular cloning: a laboratory manual, 2nd Ed. New York: Cold Spring Harbor Laboratory Press, 1989, pp. 9.16–9.19.
  26. Ha PK, Eisele DW, Frassica FJ, Zahurak ML, McCarthy EF. Osteosarcoma of the head and neck: a review of the Johns Hopkins experience. Laryngoscope. 1999;109(6):964–969
  27. Malkin D, Li FP, Strong LC, Fraumeni JF, Nelson CE, Kim DH, et al.  Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science. 1990;250(4985):1233–1238
  28. Goorin AM, Abelson HT, Frei E. Osteosarcoma: fifteen years later. N Engl J Med. 1985;313(26):1637–1643
  29. Clark JL, Unni KK, Dahlin DC, Devine KD. Osteosarcoma of the jaw. Cancer. 1983;51(12):2311–2316
  30. Oda D, Bavisotto LM, Schmidt RA, McNutt M, Bruckner JD, Conrad EU, et al. Head and neck osteosarcoma at the University of Washington. Head Neck. 1997;19(6):513–523
  31. Caron AS, Hajdu SI, Strong EW. Osteogenic sarcoma of the facial and cranial bones. A review of forty-three cases. Am J Surg. 1971;122(6):719–725
  32. Garrington GE, Scofield HH, Cornyn J, Hooker SP. Osteosarcoma of the jaws. Analysis of 56 cases. Cancer. 1967;20(3):377–391
  33. Bertoni F, Dallera P, Bacchini P, Marchetti C, Campobassi A. The Istituto Rizzoli-Beretta experience with osteosarcoma of the jaw. Cancer. 1991;68(7):1555–1563
  34. Lewis M, Perl A, Som PM, Urken ML, Brandwein MS. Osteogenic sarcoma of the jaw. A clinicopathologic review of 12 patients. Arch Otolaryngol Head Neck Surg. 1997;123(2):169–174
  35. deFries HO, Perlin E, Leibel SA. Treatment of osteogenic sarcoma of the mandible. Arch Otolaryngol. 1979;105(6):358–359
  36. Kassir RR, Rassekh CH, Kinsella JB, Segas J, Carrau RL, Hokanson JA. Osteosarcoma of the head and neck: meta-analysis of nonrandomized studies. Laryngoscope. 1997;107(1):56–61
  37. Miller CW, Aslo A, Won A, Tan M, Lampkin B, Koeffler HP. Alterations of the p53, Rb and MDM2 genes in osteosarcoma. J Cancer Res Clin Oncol. 1996;122(9):559–565
  38. Kanoe H, Nakayama T, Murakami H, Hosaka T, Yamamoto H, Nakashima Y, et al.  Amplification of the CDK4 gene in sarcomas: tumor specificity and relationship with the RB gene mutation. Anticancer Res. 1998;18(4A):2317–2321
  39. Lonardo F, Ueda T, Huvos AG, Healey J, Ladanyi M. p53 and MDM2 alterations in osteosarcomas: correlation with clinicopathologic features and proliferative rate. Cancer. 1997;79(8):1541–1547
  40. Ragazzini P, Gamberi G, Benassi MS, Orlando C, Sestini R, Ferrari C, et al.  Analysis of SAS gene and CDK4 and MDM2 proteins in low-grade osteosarcoma. Cancer Detect Prev. 1999;23(2):129–136
  41. Ladanyi M, Cha C, Lewis R, Jhanwar SC, Huvos AG, Healey JH. MDM2 gene amplification in metastatic osteosarcoma. Cancer Res. 1993;53(1):16–18
  42. Yokoyama R, Schneider-Stock R, Radig K, Wex T, Roessner A. Clinicopathologic implications of MDM2, p53 and K-ras gene alterations in osteosarcomas: MDM2 amplification and p53 mutations found in progressive tumors. Pathol Res Pract. 1998;194(9):615–621
  43. Benassi MS, Molendini L, Gamberi G, Ragazzini P, Sollazzo MR, Merli M, et al.  Alteration of pRb/p16/cdk4 regulation in human osteosarcoma. Int J Cancer. 1999;84(5):489–493
  44. Nakayama T, Toguchida J, Wadayama B, Kanoe H, Kotoura Y, Sasaki MS. MDM2 gene amplification in bone and soft-tissue tumors: association with tumor progression in differentiated adipose-tissue tumors. Int J Cancer. 1995;64(5):342–346
  45. Noble-Topham SE, Burrow SR, Eppert K, Kandel RA, Meltzer PS, Bell RS, et al.  SAS is amplified predominantly in surface osteosarcoma. J Orthop Res. 1996;14(5):700–705

PII: S1368-8375(00)00130-5

Oral Oncology
Volume 37, Issue 7 , Pages 566-571 , October 2001