Oral Oncology
Volume 37, Issue 4 , Pages 351-356 , June 2001

Homozygous deletions on the short arm of chromosome 3 in human oral squamous cell carcinomas

  • N. Uzawa

      Affiliations

    • Maxillofacial Surgery, Maxillofacial Reconstruction and Function, Division of Maxillofacial and Neck Reconstruction, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81-3-5803-0198; fax: +81-3-5803-5502
  • ,
  • D. Akanuma

      Affiliations

    • Maxillofacial Surgery, Maxillofacial Reconstruction and Function, Division of Maxillofacial and Neck Reconstruction, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan
  • ,
  • A. Negishi

      Affiliations

    • Department of Oral and Maxillofacial Surgery, School of Medicine, Gunma University, 3-39-22 showa-machi, Maebashi-shi, Gunma 371-8511, Japan
  • ,
  • H. Iwaki

      Affiliations

    • Maxillofacial Surgery, Maxillofacial Reconstruction and Function, Division of Maxillofacial and Neck Reconstruction, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan
  • ,
  • Y. Uzawa

      Affiliations

    • Maxillofacial Surgery, Maxillofacial Reconstruction and Function, Division of Maxillofacial and Neck Reconstruction, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan
  • ,
  • T. Amagasa

      Affiliations

    • Maxillofacial Surgery, Maxillofacial Reconstruction and Function, Division of Maxillofacial and Neck Reconstruction, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan
  • ,
  • M.A. Yoshida

      Affiliations

    • Laboratory of Molecular Cytogenetics, Department of Chemotherapy, Institute for Clinical Research, National Kyushu Cancer Center, 3-1-1 Notame, Minami-ku, Fukuoka 811-1395, Japan

Received 26 July 2000 ,Accepted 21 August 2000.

References 

  1. Johnson NW. A global view of the epidemiology of oral cancer. In: Johnson NW, editor. Risk markers for oral diseases, vol. 2. Oral cancer, detection of patients and lesion at risk. Cambridge: Cambridge University Press, 1991. p. 1–26.
  2. Vokes EE, Weichselbaum RR, Lippman SM, Hong WK. Head and neck cancer. N Engl J Med. 1993;328(3):184–194
  3. Somers KD, Cartwright SL, Schechter GL. Amplification of the int-2 gene in human head and neck squamous cell carcinomas. Oncogene. 1990;5:915–920
  4. Sakai E, Rikimaru K, Ueda M, Matsumoto Y, Ishii N, Enomoto S, et al.  The p53 tumor-suppressor gene and ras oncogene mutations in oral squamous-cell carcinoma. Int J Cancer. 1992;52:867–872
  5. Uzawa K, Yoshida H, Suzuki H, Tanzawa H, Shimazaki J, Seino S, et al.  Abnormalities of the adenomatous polyposis coli gene in human oral squamous-cell carcinoma. Int J Cancer. 1994;58:814–817
  6. Roz L, Wu CL, Porter SR, Scully C, Read A, Sloan P, et al. Allelic imbalance on chromosome 3p in oral dysplastic lesions (an early event in oral carcinogenesis). Cancer Research. 1996;56:1228–1231
  7. Maestro R, Gasparotto D, Vukosavljevic T, Barzan L, Sulfaro S, Boiocchi M. Three discrete regions of deletion at 3p in head and neck cancers. Cancer Res. 1993;53:5775–5779
  8. Wu CL, Sloan P, Read AP, Harris R, Thakker N. Deletion mapping on the short arm of chromosome 3 in squamous cell carcinoma of the oral cavity. Cancer Res. 1994;54:6484–6488
  9. Uzawa N, Yoshida MA, Oshimura M, Ikeuchi T. Suppression of tumorigenicity in three different cell lines of human oral squamous cell carcinoma by introduction of chromosome 3p via microcell-mediated chromosome transfer. Oncogene. 1995;11:1997–2004
  10. Uzawa N, Yoshida MA, Hosoe S, Oshimura M, Amagasa T, Ikeuchi T. Functional evidence for involvement of multiple putative tumor suppressor genes on the short arm of chromosome 3 in human oral squamous cell carcinogenesis. Cancer Genet Cytogenet. 1998;107:125–131
  11. Dryja TP, Cavenee W, White R, Rapaport JM, Peterson R, Albert DM, et al.  Homozygosity of chromosome 13 in retinoblastoma. N Engl J Med. 1984;310:550–553
  12. Lewis WH, Yeger H, Bonetta L, Chan HSL, Kang J, Junien C, et al.  Homozygous deletion of a DNA marker from chromosome 11p13 in sporadic Wilms' tumor. Genomics. 1989;3:25–31
  13. Rabbitts P, Bergh J, Douglas J, Collins F, Waters J. A submicroscopic homozygous deletion at the D3S3 locus in a cell line isolated from a small cell lung carcinoma. Genes Chromosomes Cancer. 1990;2:231–238
  14. Yamakawa K, Takahashi T, Horio Y, Murata Y, Takahashi E, Hibi K, et al.  Frequent homozygous deletions in lung cancer cell lines detected by a DNA marker located at 3p21.3-p22. Oncogene. 1993;8:327–330
  15. Daly MC, Xiang RH, Buchhagen D, Hensel CH, Garcia DK, Killary AM, et al.  A homozygous deletion on chromosome 3 in a small cell lung cancer cell line correlates with a region of tumor suppressor activity. Oncogene. 1993;8:1825–1832
  16. Kok K, van den Berg A, Veldhuis PM, van der Veen AY, Franke M, Schoenmakers EF, et al.  A homozygous deletion in a small cell lung cancer cell line involving a 3p21 region with a marked instability in yeast artificial chromosome. Cancer Res. 1994;54:4183–4187
  17. Kastury K, Baffa R, Druck T, Ohta M, Cotticelli MG, Inoue H, et al.  Potential gastrointestinal tumor suppressor locus at the 3p14.2 FRA3B site identified by homozygous deletions in tumor cell lines. Cancer Res. 1996;56:978–983
  18. Roche J, Boldog F, Robinson M, Robinson L, Varella-Garcia M, Swanton M, et al.  Distinct 3p21.3 deletions in lung cancer and identification of a new human semaphorin. Oncogene. 1996;12:1289–1297
  19. Ohta M, Inoue H, Cotticelli MG, Kastury K, Baffa R, Palazzo J, et al.  The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers. Cell. 1996;84:587–597
  20. Sozzi G, Veronese ML, Negrini M, Baffa R, Cotticelli MG, Inoue H, et al.  The FHIT gene at 3p14.2 is abnormal in lung cancer. Cell. 1996;85:17–25
  21. Negrini M, Monaco C, Vorechovsky I, Ohta M, Druck T, Baffa R, et al.  The FHIT gene at 3p14.2 is abnormal in breast carcinoma. Cancer Res. 1996;56:3173–3179
  22. Mao L, Fan YH, Lotan R, Hong WK. Frequent abnormalities of FHIT, a candidate tumor suppressor gene, in head and neck cancer cell lines. Cancer Res. 1996;56:5128–5131
  23. Van den Berg A, Kooy RF, Hulsbeek MMF, de Jong D, Kok K, van der Veen AY, et al.  Ordering of polymorphic markers in the chromosome region 3p21. Cytogenet Cell Genet. 1996;72:225–228
  24. Fong KM, Biesterveld EJ, Virmani A, Wistuba I, Sekido Y, Bader SA, et al.  FHIT and FRA3B 3p14.2 allele loss are common in lung cancer and preneoplastic bronchial lesions and are associated with cancer-related FHIT cDNA splicing aberrations. Cancer Res. 1997;57:2256–2267
  25. Buchhagen DL, Qiu L, Etkind P. Homozygous deletion, rearrangement and hypermethylation implicate chromosome region 3p14. 3-3p21.3 in sporadic breast-cancer development. Int J Cancer. 1994;57:473–479
  26. Chen F, Kishida T, Duh FM, Renbaum P, Orcutt ML, Scmidt L, et al.  Suppression of growth of renal carcinoma cells by the von Hippel-Lindau tumor suppressor gene. Cancer Res. 1995;55:4804–4807
  27. Aburatani H, Wabg Y, Shibata H, Noda T, Schwartz D, Housman DE. Identification of a region of homozygous deletion in cervical carcinoma. Am. J. Hum. Genet. 1994;55:A51
  28. Boldog F, Gemmill RM, West J, Robinson M, Robinson L, Li E, et al.  Chromosome 3p14 homozygous deletions and sequence analysis of FRA3B. Hum Mol Genet. 1997;6.2:193–203
  29. Wang L, Darling J, Zhang JS, Qian CP, Hartmann L, Conover C, et al.  Frequent homozygous deletions in the FRA3B region in tumor cell lines still leave the FHIT exons intact. Oncogene. 1998;16:635–642
  30. Brzoska PM, Levin NA, Fu KK, Kaplan MJ, Singer MI, Gray JW, et al.  Frequent novel DNA copy number increase in squamous cell head and neck tumors. Cancer Res. 1995;55:3055–3059
  31. Partridge M, Emilion G, Pateromichelakis S, Phillips E, Langdon J. Location of candidate tumor suppressor gene loci at chromosome 3p, 8p and 9p for oral squamous cell carcinomas. Int J Cancer. 1999;83:318–325
  32. Mao L. Tumor suppressor genes: Does FHIT fit?. J Natl Can Inst. 1998;60(6):412–414
  33. Kok K, Naylor SL, Buys CHCM. Deletion of the short arm of chromosome 3 in solid tumor and the search for suppressor genes. Adv Cancer Res. 1997;28–92
  34. van Heerden WFP, Swart TJP, van Heerden MB, van Rensburg EJ, Engelbrecht S, Dreyer L, et al.  Immunohistochemical evaluation of Fhit protein expression in oral squamous cell carcinomas. J Oral Pathol Med. 1999;28:433–437
  35. Siprashvoli Z, Sozzi G, Barnes LD, McCue P, Robinson AK, Eryomin V, et al.  Replacement of Fhit in cancer cells suppresses tumorigenicity. Proc Natl Acad Sci USA. 1997;94:13771–13776

PII: S1368-8375(00)00095-6

Oral Oncology
Volume 37, Issue 4 , Pages 351-356 , June 2001