Oral Oncology
Volume 37, Issue 1 , Pages 84-93 , January 2001

Preserved salivary output and xerostomia-related quality of life in head and neck cancer patients receiving parotid-sparing radiotherapy

  • B.S. Henson

      Affiliations

    • Department of Oral Medicine, Pathology, Oncology, University of Michigan School of Dentistry, USA
  • ,
  • M.R. Inglehart

      Affiliations

    • Department of Periodontics, Prevention, Geriatrics, University of Michigan School of Dentistry, USA
  • ,
  • A. Eisbruch

      Affiliations

    • Department of Radiation Oncology; University of Michigan Medical School, Ann Arbor, MI 48109-1078, USA
  • ,
  • J.A. Ship

      Affiliations

    • Department of Oral Medicine, Pathology, Oncology, University of Michigan School of Dentistry, USA
    • Corresponding Author InformationCorresponding author. Present address: Division of Biological Sciences, Medicine, Surgery and Clinical Research Center, New York University College of Dentistry, 345 East 24th Street, New York, NY 10010-4086, USA. Tel.: +1-212-998-9543; fax: +1-212-995-4087

Received 17 April 2000 ,Accepted 15 May 2000.

References 

  1. Greenlee RT, Murray T, Bolden S, Wingo PA. Cancer statistics, 2000. Ca Cancer J. Clin. 2000;50:7–33
  2. Parsons JT. The effect of radiation on normal tissues of the head and neck. In:  Million RR,  Cassisi NJ editor. Management of head and neck cancer. A multidisciplinary approach. 2nd ed. Philadelphia, PA: J.B. Lippincott Co; 1994;p. 245–289
  3. Valdez IH, Atkinson JC, Ship JA, Fox PC. Major salivary gland function in patients with radiation-induced xerostomia: flow rates and sialochemistry. Int J Rad Oncol Biol Phys. 1993;25:41–47
  4. Epstein JB, Emerton S, Kolbinson DA, Le ND, Phillips N, Stevenson-Moore P, et al.  Quality of life and oral function following radiotherapy for head and neck cancer. Head Neck. 1999;21(1):1–11
  5. Bjordal K, Ahlner-Elmqvist M, Tollesson E, Jensen AB, Razavi D, Maher EJ, et al.  Development of a European Organization for Research and Treatment of Cancer (EORTC) questionnaire module to be used in quality of life assessments in head and neck cancer patients. EORTC Quality of Life Study Group. Acta Oncologica. 1994;33(8):879–885
  6. Bjordal K, Kaasa S, Mastekaasa A. Quality of life in patients treated for head and neck cancer: a follow-up study 7 to 11 years after radiotherapy. Int J Rad Oncol Biol Phys. 1994;28(4):847–856
  7. Bjordal K, Freng A, Thorvik J, Kaasa S. Patient self-reported and clinician-rated quality of life in head and neck cancer patients: a cross-sectional study. Oral Oncology. 1995;4:235–241
  8. Bjordal K, Kaasa S. Psychological distress in head and neck cancer patients 7–11 years after curative treatment. Brit J. Cancer. 1995;71(3):592–597
  9. Bjordal K, Hammerlid E, Ahlner-Elmqvist M, de Graeff A, Boysen M, Evensen JF, et al.  Quality of life in head and neck cancer patients: validation of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (H&N35). J Clin Oncol. 1999;17(3):1008–1019
  10. Browman GP, Levine MN, Hodson DI, Sathya J, Russell R, Skingley P, et al.  The head and neck radiotherapy questionnaire: a morbidity/quality-of-life instrument for clinical trials of radiation therapy in locally advanced head and neck cancer. J Clin Oncol. 1993;11(5):863–872
  11. List MA, Siston A, Haraf D, Schumm P, Kies M, Stenson K, et al.  Quality of life and performance in advanced head and neck cancer patients on concomitant chemoradiotherapy: a prospective examination. J Clin Oncol. 1999;17(3):1020–1028
  12. List MA, Mumby P, Haraf D, Siston A, Mick R, MacCracken E, et al.  Performance and quality of life outcome in patients completing concomitant chemoradiotherapy protocols for head and neck cancer. Qual Life Res. 1997;6(3):274–284
  13. List MA, Ritter-Sterr CA, Baker TM, Colangelo LA, Matz G, Pauloski BR, et al.  Longitudinal assessment of quality of life in laryngeal cancer patients. Head Neck. 1996;18(1):1–10
  14. List MA, Ritter-Sterr C, Lansky SB. A performance status scale for head and neck cancer patients. Cancer. 1990;66(3):564–569
  15. Zelefsky MJ, Gaynor J, Kraus D, Strong EW, Shah JP, Harrison LB. Long-term subjective functional outcome of surgery plus postoperative radiotherapy for advanced stage oral cavity and oropharyngeal carcinoma. Amer J. Surg. 1996;171(2):258–261
  16. Harrison LB, Zelefsky MJ, Pfister DG, Carper E, Raben A, Kraus DH, et al.  Detailed quality of life assessment in patients treated with primary radiotherapy for squamous cell cancer of the base of the tongue. Head Neck. 1997;19(3):169–175
  17. Jensen AB, Hansen O, Jorgensen K, Bastholt L. Influence of late side-effects upon daily life after radiotherapy for laryngeal and pharyngeal cancer. Acta Oncologica. 1994;33(5):487–491
  18. Beeken L, Calman F. A return to “normal eating” after curative treatment for oral cancer. What are the long-term prospects?. Oral Oncol. 1994;6:387–392
  19. Ship JA, Eisbruch A, D'Hondt E, Jones RE. Parotid sparing study in head and neck cancer patients receiving bilateral radiation therapy: 1 year results. J Dent Res. 1997;76:807–813
  20. Jones RE, Takeuchi T, Eisbruch A, Hazuka M, Ship JA. Ipsilateral parotid sparing study in head and neck cancer patients receiving radiation therapy: 1 year results. Oral Surg Oral Med Oral Path Oral Radiol Endo. 1996;81:642–648
  21. Eisbruch A, Ship JA, Martel MK, Ten Haken RK, Marsh LH, Wolf GT, et al.  Parotid gland sparing in patients undergoing bilateral head and neck irradiation: techniques and early results. Int J Rad Oncol Biol Phys. 1996;36(2):469–480
  22. Eisbruch A, Marsh LH, Martel MK, Ship JA, Ten Haken R, Pu AT, et al.  Comprehensive irradiation of head and neck cancer using conformal multisegmental fields: assessment of target coverage and noninvolved tissue sparing. Int J Rad Oncol Biol Phys. 1998;41(3):559–568
  23. Eisbruch A, Ten Haken RK, Kim HM, Marsh LH, Ship JA. Dose, volume, and function relationships in parotid salivary glands following conformal and intensity modulated irradiation of head and neck cancer. Int J Rad Oncol Biol Phys. 1999;45(3):577–587
  24. Henson BS, Eisbruch A, D'Hondt E, Ship JA. Two-year longitudinal study of parotid salivary flow rates in head and neck cancer patients receiving unilateral neck parotid-sparing radiotherapy treatment. Oral Oncol. 1999;35(3):234–241
  25. D'Hondt E, Eisbruch A, Ship JA. The influence of pre-radiation salivary flow rates and radiation dose on parotid salivary gland dysfunction in patients receiving radiotherapy for head and neck cancers. Spec Care Dent. 1998;18(3):102–108
  26. Mor V, Laliberte L, Morris JN, Wiemann M. The Karnofsky Performance Status Scale. An examination of its reliability and validity in a research setting. Cancer. 1984;53(9):2002–2007
  27. Baum BJ. Evaluation of stimulated parotid saliva flow rate in different age groups. J. Dent Res. 1981;60(7):1292–1296
  28. Heft MW, Baum BJ. Unstimulated and stimulated parotid salivary flow rate in individuals of different ages. J. Dent Res. 1984;63(10):1182–1185
  29. Cushing AM, Sheiham A, Maizels J. Developing socio-dental indicators — the social impact of dental disease. Comm Dent Health. 1986;3(1):3–17
  30. Locker D. Measuring oral health: a conceptual framework. Comm Dent Health. 1988;5(1):3–18
  31. Gooch BF, Dolan TA, Bourque LB. Correlates of self-reported dental health status upon enrollment in the Rand Health Insurance Experiment. J Dent Educ. 1989;53(11):629–637
  32. Atchison KA, Dolan TA. Development of the Geriatric Oral Health Assessment Index. J. Dent Educ. 1990;54(11):680–687
  33. Strauss RP, Hunt RJ. Understanding the value of teeth to older adults: influences on the quality of life. J. Amer Dent Assoc. 1993;124(1):105–110
  34. Slade GD, Spencer AJ. Development and evaluation of the Oral Health Impact Profile. Comm Dent Health. 1994;11(1):3–11
  35. Kressin N, Spiro A, Bosse R, Garcia R, Kazis L. Assessing oral health-related quality of life: findings from the normative aging study. Medical Care. 1996;34(5):416–427
  36. Leao A, Sheiham A. The development of a socio-dental measure of dental impacts on daily living. Comm Dent Health. 1996;13(1):22–26
  37. Fox PC, Busch KA, Baum BJ. Subjective reports of xerostomia and objective measures of salivary gland performance. J. Amer Dent Assoc. 1987;115(4):581–584
  38. Zimmerman RP, Mark RJ, Tran LM, Juillard GF. Concomitant pilocarpine during head and neck irradiation is associated with decreased posttreatment xerostomia. Int J. Rad Oncol Biol Phys. 1997;37(3):571–575
  39. Ship JA, Fox PC, Baum BJ. Normal salivary gland function: how much saliva is enough?. J Amer Dent Assoc. 1991;122:63–69
  40. Copeland EM, Ellis LM. Nutritional management in patients with head and neck malignancies. In:  Million RR,  Cassisi NJ editor. Management of head and neck cancer. A multidisciplinary approach, 2nd ed.. Philadelphia, PA: J.B. Lippincott Co; 1994;p. 193–201
  41. Sonis ST, Eilers JP, Epstein JB, LeVeque FG, Liggett WH, Mulagha MT, et al.  Validation of a new scoring system for the assessment of clinical trial research of oral mucositis induced by radiation or chemotherapy. Mucositis Study Group. Cancer. 1999;85(10):2103–2113
  42. Ship JA, Chavez EM, Gould KL, Henson BS, Sarmadi M. Evaluation and management of oral cancer. Home Hlth Care Consult. 1999;6(4):2–12
  43. Tabak LA. In defense of the oral cavity: structure, biosynthesis, and function of salivary mucins. Ann Rev Physiol. 1995;57:547–564

PII: S1368-8375(00)00063-4

Oral Oncology
Volume 37, Issue 1 , Pages 84-93 , January 2001