Oral Oncology
Volume 37, Issue 1 , Pages 72-76, January 2001

Volume-corrected mitotic index as a prognostic factor in oral squamous cell carcinomas

Department of Oral and Maxillofacial Surgery, Dokkyo University School of Medicine, 880 Kita-kobayashi, Mibu, Tochigi 321-0293, Japan

Received 14 February 2000; accepted 18 February 2000.

Abstract 

In order to predict the prognosis of patients with oral squamous cell carcinomas, volume-corrected mitotic index (M/V index), as well as histopathological and clinical indices were estimated in 50 oral squamous cell carcinoma tumors. Histological malignancy (P=0.0005), mode of invasion (P=0.0168) and M/V index (P=0.0093) showed a significant correlation with survival according to univariate survival analysis. According to multivariate survival analysis (Cox's regression model), the M/V index was the best predictor of the techniques studied of patient prognosis. The M/V index also showed significant correlation with DNA ploidy. The present results suggest that the M/V index is an important prognostic factor for oral carcinoma. Furthermore, the M/V index and DNA ploidy appear to provide similar prognostic information.

Keywords:  Oral squamous cell carcinoma, Prognostic factor, Volume-corrected mitotic index (M/V index)

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PII: S1368-8375(00)00061-0

Oral Oncology
Volume 37, Issue 1 , Pages 72-76, January 2001

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