Oral Oncology
Volume 37, Issue 1 , Pages 57-64 , January 2001

The pattern of expression of the 5T4 oncofoetal antigen on normal, dysplastic and malignant oral mucosa

  • A. Ali

      Affiliations

    • Maxillofacial Unit/Molecular Oncology, King's College Hospital, Denmark Hill, London SE5 8RX, UK
  • ,
  • J. Langdon

      Affiliations

    • Maxillofacial Unit/Molecular Oncology, King's College Hospital, Denmark Hill, London SE5 8RX, UK
  • ,
  • P. Stern

      Affiliations

    • Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester M20 4BX, UK
  • ,
  • M. Partridge

      Affiliations

    • Maxillofacial Unit/Molecular Oncology, King's College Hospital, Denmark Hill, London SE5 8RX, UK
    • Corresponding Author InformationCorresponding author. Tel.: +44-20-7346-3474; fax: +44-20-7346-3754

Received 16 February 2000 ,Accepted 27 March 2000.

References 

  1. Hole N, Stern PL. A 72kD trophoblast glycoprotein defined by a monoclonal antibody. British Journal of Cancer. 1988;57:239–246
  2. Southall P, Boxer G, Bagshawe KD, Hole N, Bromley M, Stern PL. Immunohistological distribution of 5T4 antigens in normal and malignant tissue. British Journal of Cancer. 1990;61:89–95
  3. King K, Sheppard F, Westwater C, Stern PL, Myers KM. Organisation of the mouse and human 5T4 oncofoetal leucine rich glycoprotein genes and expression in foetal and adult murine tissues. Biochemica et Biophysica Acta. 1999;1445:257–270
  4. Starzynska T, Marsh PJ, Schofield PF, Roberts SA, Myers KA, Stern PL. Prognostic significance of 5T4 oncofetal antigen expression in colorectal carcinoma. British Journal of Cancer. 1994;69:899–902
  5. Mulder WMC, Stern PL, Stukart MJ, et al.  Low ICAM-1 and high 5T4 expression on tumour cells independently correlates with disease-free survival in colorectal carcinoma patients. Clinical Cancer Research. 1997;3:1923–1930
  6. Starzynska T, Wiechowska-Kozlowska A, Marlicz K, et al.  Expression of 5T4 oncofetal antigen in relation to the origins of gastric carcinoma and clinical outcome. European Journal of Gastroenterology and Hepatology. 1998;10:479–484
  7. Wrigley E, McGown AT, Rennison J, et al.  5T4 oncofetal antigen expression in ovarian carcinoma. International Journal Gynaecological Cancer. 1995;5:269–274
  8. Jones H, Roberts G, Hole N, McDicken IW, Stern PL. Investigation of 5T4 antigen expression in cervical cancer. British Journal of Cancer. 1990;61:96–100
  9. Carsberg CJ, Myers KA, Evans GS, Allen TD, Stern PL. Metastasis associated 5T4 oncofetal antigen is concentrated at microvillus projections of the plasma membrane. Journal of Cell Science. 1995;108:2905–2916
  10. Carsberg CJ, Myers KA, Stern PL. Metastasis-associated 5T4 antigen disrupts cell–cell contacts and induces cellular motility in epithelial cells. International Journal of Cancer. 1996;68:84–92
  11. Hole N, Stern PL. Isolation and characterization of 5T4, a tumour-associated antigen. International Journal of Cancer. 1990;45:179–184
  12. Myers KA, Rahi-Saund V, Davison MD, Youngs JA, Cheater AJ, Stern PL. Isolation of a cDNA encoding the 5T4 oncofetal trophoblast glycoprotein. Journal of Biological Chemistry. 1994;12:9319–9324
  13. Buchanan SG, Gay NJ. Structural and functional diversity in the leucine-rich repeat family of proteins. Progress in Biophysics and Molecular Biology. 1996;65(1–2):1–44
  14. Partridge M, Emilion G, Langdon JD. LOH at 3p correlates with a poor survival in oral squamous cell carcinoma. British Journal of Cancer. 1996;73:366–371
  15. Partridge M, Emilion G, Pateromichelakis S, A'Hern R, Phillips E, Langdon J. Allelic imbalance at chromosomal loci implicated in the pathogenesis of oral precancer; cumulative loss and its relationship with progression to cancer. European Journal of Cancer, Oral Oncology. 1998;34:77–83
  16. Starzynska T, Rahi V, Stern PL. The expression of 5T4 antigen in colorectal and gastric carcinomas. British Journal of Cancer. 1992;66:867–869

PII: S1368-8375(00)00057-9

Oral Oncology
Volume 37, Issue 1 , Pages 57-64 , January 2001